Opening Keynote: Conceptualising THR and balancing clinical and population considerations

Peter will discuss the conceptual framework of total community harm reduction that involves the dynamic balance between products, practices, and policies that affect the availability and consumption of tobacco products. He will then describe project VECTOR (Vaping and Electronic Cigarette Toxicity Overview and Recommendations)  where his team used systematic and umbrella reviews and a consensus-driven approach with a panel of 30 international academics and individuals with lived experience. They voted on recommendations related to four key health outcomes: cancer, cardiovascular disease, respiratory health, and dependence. The consensus resulted in 14 recommendations, each assessed for evidence quality and strength. Four accompanying knowledge products were developed to support decision-making.  He will describe the recommendations and considerations for people who currently use or are thinking of using e-cigarettes, and discuss how these recommendations can be applied in clinical practice and population-level health considerations to balance absolute versus relative risk in a time of evolving evidence.